A recent study reveals that patients who stop using blockbuster GLP-1 drugs like Mounjaro or Wegovy can put back on lost weight much more quickly than those who end traditional lifestyle programs.
Findings released in a prominent medical journal points out that while obese people frequently drop about a fifth of their body weight while undergoing treatment, the mass returns at an average rate of 0.8 kg per month after stopping.
"Individuals purchasing these drugs need to be informed of the danger of quick rebound weight gain when the treatment concludes," stated researcher Dr. Susan Jebb.
Such speed of recovery implies a reversion to pre-treatment mass within about a year and a half.
Comparing Approaches
The analysis, which looked at dozens of trials involving over 9,000 of participants, contrasted the results of these new drugs with other pills.
The team point out that people who lose weight through dieting generally experience a more gradual creep back—around 100 grams monthly—after stopping.
Understanding the Fast Regain
Experts propose the way of the injections is key to understanding the heightened weight return.
The injections imitate a body's own chemical called GLP-1, which helps regulate appetite.
"Artificially providing the hormone levels far above than normal could lead to the system to generate a reduced amount of its endogenous hormone, and could lessen responsiveness to its actions," said Dr. Adam Collins, a nutrition expert.
"Stopping of this medication results in appetite is no longer kept in check, making binge eating much more probable."
An Ongoing Disease?
Health authorities suggest the injections for people with weight-linked medical conditions, accompanied by prescribed diet and exercise modifications.
A number of clinicians contend that, given the significant potential of weight regain, the treatment is often life-long.
This opinion is echoed by pharmaceutical companies, who say that the results "underscore the long-term character of obesity," similar to managing diseases like high blood pressure.
Patient Experiences
People who have come off the medication explain a powerful return of cravings.
"It was like a trigger that goes on and you're instantly extremely hungry," described a patient.
The struggle is worsened if patients have not developed sustainable lifestyle or habit changes during treatment.
Growing Use
Figures indicate that millions of people in the UK have tried weight-loss jabs in the last 12 months, with demand continuing to grow.
- Adoption is more common among females compared to males.
- The middle-aged age group shows the highest level of interest.
- Many obtain the medications through private healthcare rather than public health services.
Finally, clinicians stress that while these medications are effective tools for weight loss, they are not a standalone cure and long-term success relies on integrated behavioural management.
